The A420 has been closed as emergency services deal with a multi-vehicle crash.
The major road is blocked in both directions by police between Faringdon and Buckland following a road traffic collision after 1pm this afternoon (Monday).
There are significant traffic delays for motorists, with vehicles diverting via Hatford and Gainfield to bypass the incident.
According to Stagecoach, the bus company, the police have advised that the route will remain closed for three to four hours.